abstract：:There is an extensive literature on sexual disorders among diabetic patients, but a shortage of studies on their prevalence in selection-free populations. In the present trial (JEVIN), 90% of all insulin-treated diabetic patients (IDDM/NIDDM, n = 127/117) aged 16-60 years and living in the city of Jena (100247 inhabit...

journal_title：Diabetes research and clinical practice

authors： Schiel R,Müller UA

更新日期：1999-05-01 00:00:00

abstract：:The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) and their relationship to age and obesity was estimated in a population-based survey in urban and rural areas in Baluchistan province, Pakistan. Cluster sampling of 834 adults (260 men, 574 women) in the urban and 570 adults (175 men, 395 wo...

journal_title：Diabetes research and clinical practice

authors： Shera AS,Rafique G,Khawaja IA,Baqai S,King H

更新日期：1999-04-01 00:00:00

abstract：:Genetic predisposition to haemochromatosis may be an important aetiological factor in some cases of Type 2 diabetes. Our aim was therefore to test the hypothesis that the haemochromatosis gene mutations Cys282Tyr and His63Asp are more prevalent in Type 2 diabetic patients compared with the Canterbury, New Zealand gene...

journal_title：Diabetes research and clinical practice

authors： Florkowski CM,George PM,Willis JA,Stott MK,Burt MJ,Upton JD,Nesbit J,Walmsley TA,Scott RS

更新日期：1999-03-01 00:00:00

abstract：:Aminoguanidine, an inhibitor of advanced glycation reactions in vitro, inhibits the development of diabetic complications in animal models of diabetes, suggesting that it acts by inhibition of advanced glycation reactions in vivo. However, effects of aminoguanidine on the formation of specific advanced glycation end-p...

journal_title：Diabetes research and clinical practice

authors： Degenhardt TP,Fu MX,Voss E,Reiff K,Neidlein R,Strein K,Thorpe SR,Baynes JW,Reiter R

更新日期：1999-02-01 00:00:00

abstract：:This retrospective study presents the mortality trends in diabetic patients in a developing region of the world. The data were collected by screening the hospital records of all diabetic patients who died over a period of a decade at Institute of Medical Sciences, a tertiary care medical centre in Kashmir Valley of In...

journal_title：Diabetes research and clinical practice

authors： Zargar AH,Wani AI,Masoodi SR,Laway BA,Bashir MI

更新日期：1999-01-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is a major clinical and public health problem in Kuwait. The objective of the study was to determine prevalence rates of NIDDM among a representative sample of the Kuwaiti adult population aged 20 and older in two out of five governorates and identify the associated risk...

journal_title：Diabetes research and clinical practice

authors： Abdella N,Al Arouj M,Al Nakhi A,Al Assoussi A,Moussa M

更新日期：1998-12-01 00:00:00

abstract：:The study of diabetic neuropathy has been primarily in Europids, despite the high prevalence of diabetes in other populations. We set out to ascertain the prevalence of diabetic neuropathy and its risk factors in the island nation of Mauritius. Population surveys were carried out in 1987 and 1992 in Mauritius to estab...

journal_title：Diabetes research and clinical practice

authors： Shaw JE,Hodge AM,de Courten M,Dowse GK,Gareeboo H,Tuomilehto J,Alberti KG,Zimmet PZ

更新日期：1998-11-01 00:00:00

abstract：:Analyses of direct effects of smoking on peripheral arteries were done using thermography, blood fluorometry and echography on 97 habitual smoker-diabetics without triopathy. There were found to be four types of thermographic changes following smoking, which varied according to the degree of atherosclerosis of the art...

journal_title：Diabetes research and clinical practice

authors： Fushimi H,Kubo M,Inoue T,Yamada Y,Matsuyama Y,Kameyama M

更新日期：1998-10-01 00:00:00

abstract：:The aim of this multicentre study was to investigate the effect--in everyday life--of long term administration of acarbose on parameters of glycaemic control, daily insulin requirements, lipid parameters and tolerability in ambulant type 1 diabetic subjects insufficiently controlled with diet and insulin. Furthermore,...

journal_title：Diabetes research and clinical practice

authors： Sels JP,Verdonk HE,Wolffenbuttel BH

更新日期：1998-08-01 00:00:00

abstract：:To evaluate the effect of pioglitazone on insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) patients, a double-blind placebo-controlled trial was carried out with 30 NIDDM patients. Twenty-one subjects, three on diet alone and 18 on sulfonylurea (SU), orally received 30 mg pioglitazone once daily f...

journal_title：Diabetes research and clinical practice

authors： Kawamori R,Matsuhisa M,Kinoshita J,Mochizuki K,Niwa M,Arisaka T,Ikeda M,Kubota M,Wada M,Kanda T,Ikebuchi M,Tohdo R,Yamasaki Y

更新日期：1998-07-01 00:00:00

abstract：:The results of various studies suggest that hypertriglyceridaemia is associated with an increased risk of coronary artery disease. It is unclear, however, which particular triglyceride (TG)-rich lipoproteins contribute to the risk. Different types of TG-rich lipoprotein differ in function, composition, size and densit...

journal_title：Diabetes research and clinical practice

authors： Steiner G

更新日期：1998-07-01 00:00:00

abstract：:There is a paucity of data regarding outcomes of Type 2 diabetes mellitus. A cohort of 447 Type 2 diabetic subjects (208 male, 239 female; age range 30-82 years, median 62 years; and of predominantly European origin) was characterised in a clinic survey in 1989. Individual status (dead or alive) at 1 June 1995 was asc...

journal_title：Diabetes research and clinical practice

authors： Florkowski CM,Scott RS,Moir CL,Graham PJ

更新日期：1998-06-01 00:00:00

abstract：:The prevalence of increased urinary albumin excretion (UAE) (micro- and macroalbuminuria) and its association with diabetic retinopathy (DR) (evaluated by fluorescent angiography), coronary heart disease (CHD), and various related risk factors were studied in 320 type 2 diabetic patients. In this subsample of type 2 d...

journal_title：Diabetes research and clinical practice

authors： Lunetta M,Infantone L,Calogero AE,Infantone E

更新日期：1998-04-01 00:00:00

abstract：:Chronic renal diseases, including diabetic nephropathy, evolve to terminal renal failure by a process leading to progressive parenchimal damage which appears relatively independent of the initial insult. When glomerular permselectivity is lost, proteins filtered through the glomerular capillary, through proximal tubul...

journal_title：Diabetes research and clinical practice

authors： Remuzzi G,Ruggenenti P

更新日期：1998-04-01 00:00:00

abstract：:In this retrospective study, the prevalence of chronic microangiopathic complications was determined in 474 Chinese patients with non-insulin dependent diabetes mellitus (NIDDM) who presented within 1 year of diagnosis to the diabetes clinic from January 1990 to December 1996. Mean age (+/- S.E.) was 53.6 (+/- 0.6) ye...

journal_title：Diabetes research and clinical practice

authors： Wang WQ,Ip TP,Lam KS

更新日期：1998-03-01 00:00:00

abstract：:The aim of our work was to study non-insulin-mediated glucose uptake (NIMGU), in the postabsorptive state, in several pathologies characterized by peripheral insulin resistance, namely, obesity (n = 10), NIDDM (n = 7), acromegaly (n = 7) and Cushing's disease (n = 6). These groups were compared with a group of 16 heal...

journal_title：Diabetes research and clinical practice

authors： García-Estévez DA,Araújo-Vilar D,Cabezas-Cerrato J

更新日期：1998-02-01 00:00:00

abstract：:The effect of a decoction of fig leaves (Ficus carica), as a supplement to breakfast, on diabetes control was studied in insulin-dependent diabetes mellitus (IDDM) patients (six men, four women, age 22-38 years, body mass index (BMI): 20.8 +/- 3.0 kg/m2, HbA1c 7.6 +/- 0.9% with a mean duration of diabetes of 9 +/- 6.3...

journal_title：Diabetes research and clinical practice

authors： Serraclara A,Hawkins F,Pérez C,Domínguez E,Campillo JE,Torres MD

更新日期：1998-01-01 00:00:00

abstract：:Proteinuria is a well known risk factor for cardiovascular morbidity. There has been no report on cardiovascular morbidity in Indian NIDDM patients with proteinuria. Hence this study has been undertaken to estimate the prevalence of cardiovascular diseases (CVD) in South Indian NIDDM with proteinuria. We studied two g...

journal_title：Diabetes research and clinical practice

authors： Viswanatham V,Snehalatha C,Mathai T,Jayaraman M,Ramachandran A

更新日期：1998-01-01 00:00:00

abstract：:Otsuka Long-Evans Tokushima Fatty (OLETF) rats are a new strain of spontaneous non-insulin-dependent diabetes mellitus (NIDDM) models. To evaluate the role of glucose transporters (GLUT) in the development of diabetes in this model, we examined the action of insulin on the translocation of GLUT4 and GLUT1 in isolated ...

journal_title：Diabetes research and clinical practice

authors： Toide K,Man ZW,Asahi Y,Sato T,Nakayama N,Noma Y,Oka Y,Shima K

更新日期：1997-12-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is implicated in the development, survival and maintenance of function of sympathetic and sensory neurons. These neurons are affected at an early stage during the course of diabetes. Reverse transcriptase polymerase chain reaction (RT-PCR) based assay revealed that rat superior cer...

journal_title：Diabetes research and clinical practice

authors： Bitar MS,Pilcher CW,Khan I,Waldbillig RJ

更新日期：1997-11-01 00:00:00

abstract：:Significant changes in gastrointestinal function, decreased gastric secretion and motility in particular, are often observed in patients with chronic diabetes. The mechanisms leading to those remain unclear. In these studies we evaluated the gastric acid secretory response to insulin and pentagastrin in normal Wistar ...

journal_title：Diabetes research and clinical practice

authors： Baydoun R,Dunbar JC

更新日期：1997-10-01 00:00:00

abstract：:Diabetic foot complications were studied in 153 patients at the university clinic in Dar es Salaam (56 insulin treated, 77 treated with oral agents and 20 with diet only). Neuropathy disability and symptoms scores were used to diagnose peripheral neuropathy (PN). Peripheral vascular disease (PVD) was classified as ank...

journal_title：Diabetes research and clinical practice

authors： Wikblad K,Smide B,Bergström A,Kessi J,Mugusi F

更新日期：1997-09-01 00:00:00

abstract：:Expansion of the glomerular mesangium is a consistent finding of diabetic nephropathy. Negatively charged proteoglycans are an integral part of the mesangium and their synthesis and degradation is disturbed in many forms of glomerulosclerosis. The metabolism of ascorbic acid (AA), which plays an important role in extr...

journal_title：Diabetes research and clinical practice

authors： McAuliffe AV,Fisher EJ,McLennan SV,Yue DK,Turtle JR

更新日期：1997-08-01 00:00:00

abstract：:We investigated how fasting or postprandial insulin levels were altered by treatment with acarbose or sulfonylureas. Plasma glucose and serum insulin, C-peptide, and proinsulin levels were measured before as well as 1 and 2 h after breakfast in 23 patients with non-insulin-dependent diabetes mellitus and 17 patients w...

journal_title：Diabetes research and clinical practice

authors： Inoue I,Takahashi K,Noji S,Awata T,Negishi K,Katayama S

更新日期：1997-06-01 00:00:00

abstract：:Vascular complications, as a consequence of atherosclerosis, are the main causes of morbidity and mortality in diabetes. Low density lipoprotein (LDL) oxidation is accepted as a relevant pathogenic mechanism in atherogenesis. The aim of this work was to study the relationship between lipid peroxidation (LPO) and metab...

journal_title：Diabetes research and clinical practice

authors： Freitas JP,Filipe PM,Rodrigo FG

更新日期：1997-05-01 00:00:00

abstract：:Increased plasma plasminogen activator inhibitor type 1 (PAI-1), coagulation factor VII (FVII) and fibrinogen levels have been recognized as risk factors for cardiovascular disease. Because a substantially high incidence of cardiovascular disease has been reported in diabetic patients with nephropathy compared with th...

journal_title：Diabetes research and clinical practice

authors： Hirano T,Kashiwazaki K,Moritomo Y,Nagano S,Adachi M

更新日期：1997-04-01 00:00:00

abstract：:The renal response to volume expansion (VE) has been shown to be impaired in streptozotocin (STZ)-induced diabetes. This may contribute to the abnormal maintenance of fluid balance in diabetics. Since calcium channel blockade (CaCb) has been shown to improve renal hemodynamic and tubular functions, the present studies...

journal_title：Diabetes research and clinical practice

authors： Patel KP,Zhang PL,Zeigler DW,Kauker ML

更新日期：1997-03-01 00:00:00

abstract：:With the objective to determine the frequency of microalbuminuria, macroalbuminuria and the associated clinic and metabolic features among insulin dependent diabetes mellitus (IDDM) Brazilian patients attending at a general University Hospital, a total of 50 outpatients, aged 21.9 +/- 7 years with IDDM duration of 6.8...

journal_title：Diabetes research and clinical practice

authors： Gomes MB,Lucchetti MR,Gazzola H,Dimetz T,Gonçalves MF,Neves R,Matos H

更新日期：1997-03-01 00:00:00

abstract：:The effects of exercise on alterations in the amount of B-cell mass, insulin content and fibrous tissue present in the pancreas were examined for a diabetic state induced by a 70% pancreatectomy and a prediabetic state in Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model for the spontaneous development of non-ins...

journal_title：Diabetes research and clinical practice

authors： Shima K,Zhu M,Noma Y,Mizuno A,Murakami T,Sano T,Kuwajima M

更新日期：1997-02-01 00:00:00

abstract：:1,5-Anhydroglucitol (1.5-AG) is known to closely reflect diabetic control within several days. The possibility of predicting long-term glycemic control after an educational hospitalization of type II diabetic patients was investigated by examining the relationship between changes in serum 1,5-AG levels after a short-t...

journal_title：Diabetes research and clinical practice

authors： Sone H,Okuda Y,Yamaoka T,Kawakami Y,Odawara M,Matsushima T,Kawai K,Yamashita K

更新日期：1996-10-01 00:00:00

abstract：:Epidemiologic studies of migrant populations provide very promising clues towards understanding the roles of genetics and environmental factors in the etiology of diabetes mellitus. Populations of Japanese ancestry are of particular interest due to marked differences in prevalence rates of non-insulin dependent diabet...

journal_title：Diabetes research and clinical practice

authors： Franco LJ

更新日期：1996-10-01 00:00:00

abstract：:HLA-DQA11 and DQB1 alleles coding for arginine (R) in position 52, and an amino acid other than aspartic acid (ND) in position 57, respectively, are strong genetic markers for IDDM in Caucasians. However, their contribution to the occurrence of the disease in Asian populations is less clear. As part of the WHO DiaMond...

journal_title：Diabetes research and clinical practice

authors： Matsuura N,Ko KW,Park YS,Elliott R

更新日期：1996-10-01 00:00:00

abstract：:A 15 year follow-up study of diabetic patients was performed in Osaka, Japan. The subjects studied were 1939 patients with non-insulin dependent diabetes mellitus (NIDDM), of whom 1000 (51.5%) were alive, 880 (45.4%) had died and 59 (3.0%) were untraceable at the end of 1993. The mortality rate per 1000 person-years o...

journal_title：Diabetes research and clinical practice

authors： Sasaki A,Uehara M,Horiuchi N,Hasegawa K,Shimizu T

更新日期：1996-09-01 00:00:00

abstract：:To clarify the pathogenesis of diabetic albuminuria at its onset, the percentage of glycated albumin (%G-albumin) in excreted urinary albumin and its negative charge were assayed. In non-diabetic albuminuria (control-A) group, the high ratio of urinary %G-albumin to serum %G-albumin (urine/serum ratio of %G-albumin) s...

journal_title：Diabetes research and clinical practice

authors： Kunika K,Yamaoka T,Itakura M

更新日期：1996-08-01 00:00:00

abstract：:Recent studies have shown both association and linkage between a Gly40-Ser mutation in the glucagon receptor gene and NIDDM in French patients with familial NIDDM. This mutation was present in heterozygous form in 4.6% of diabetic probands but only 1% of the French population, suggesting that it was an important risk ...

journal_title：Diabetes research and clinical practice

authors： Ogata M,Iwasaki N,Ohgawara H,Karibe S,Omori Y

更新日期：1996-07-01 00:00:00

abstract：:Antidiabetic sulphonylureas have attracted a great deal of interest in experimental cardiology to evaluate the role of ATP-sensitive potassium channels in the cardiovascular system. It is well established that KATP channels are present in cardiac cells and also in vascular smooth muscle cells and are implicated in the...

journal_title：Diabetes research and clinical practice

authors： Végh A,Papp JG

更新日期：1996-07-01 00:00:00

abstract：:Mutations of mitochondrial DNA have been found in cardiomyopathic and diabetic patients as well as mitochondrial myopathic patients. Mitochondrial DNA mutations are maternally transmitted. It has also been reported that these mutations can be acquired under the influence of free radicals. This article is a mini-review...

journal_title：Diabetes research and clinical practice

authors： Takeda N

更新日期：1996-07-01 00:00:00

abstract：:Patients with diabetes mellitus have a higher rate of mortality than the general population. This higher mortality may be attributed mainly to cardiovascular disease. A high prevalence of dyslipidemia in diabetics can be one of the reasons for this. The most commonly recognized lipid abnormality in non-insulin-depende...

journal_title：Diabetes research and clinical practice

authors： Yoshino G,Hirano T,Kazumi T

更新日期：1996-06-01 00:00:00

abstract：:C57BL/KsJ mice carrying homozygous db/db mutation (db/db mice) are characterized by extreme obesity and early onset of hyperglycemia. In an attempt to rectify diabetes of these mice, a pancreatic beta cell line MIN6, which retains glucose-inducible insulin secretion, was transplanted subcutaneously into the back of th...

journal_title：Diabetes research and clinical practice

authors： Inada S,Kaneko S,Suzuki K,Miyazaki J,Asakura H,Fujiwara M

更新日期：1996-05-01 00:00:00

abstract：:The aim of the present study was to evaluate the risk for vascular morbidity or death and retinopathy in relation to urinary albumin concentration. To that end, we performed a 5-year follow-up study of all type 2 diabetic patients attending the outpatient-clinic. A total of 444 (98.4%) out of 451 adult patients initia...

journal_title：Diabetes research and clinical practice

authors： Agardh CD,Agardh E,Torffvit O

更新日期：1996-04-01 00:00:00